Description

INDICATIONS
Nobilis^® IB+ND is a combined inactivated vaccine for the protection of future breeding chickens against Infectious Bronchitis (Massachusetts type) and Newcastle Disease.

COMPOSITION

Nobilis^® IB+ND contains immunogenic strains of Infectious Bronchitis virus, (Massachusetts type) and Newcastle Disease virus.
Each 0,5 mℓ dose of Nobilis^® IB+ND contains immunogenic strains of Infectious Bronchitis virus (Massachusetts type), inducing ≥ 6,0 log² HI units and Newcastle disease virus, containing at least ≥ 50 PD₅₀ units. The viruses have been inactivated with formalin and subsequently suspended in the aqueous phase of an oil adjuvant emulsion.

STORAGE

• Store in the dark between 2 °C and 8 °C.
• Do not freeze.
• Allow the vaccine to gradually reach room temperature (20 °C to 25 °C) prior to use.
• Avoid prolonged or repetitive exposure to high ambient temperatures following withdrawal from the refrigerator prior to use.
• Protect from exposure to direct sunlight.

WARNINGS

• Withdrawal period: Do not market chickens for slaughter purposes for at least 6 weeks after vaccination.
• Avoid intravenous injection.
• Ensure that chickens marketed do not have swellings at the site of vaccine administration, as this may result in the condemnation of the chickens.
• Do not mix Nobilis^® IB+ND with other vaccines.
• Vaccination of chickens in production may lead to a slight drop in egg production.
• Accidental self-vaccination may lead to a severe local allergic reaction. Consult a physician informing him/her that the vaccine contains a mineral oil.
• Do not store partially used containers for future use and use the entire contents once opened.
• Destroy all opened bottles, not used within 24 hours, as well as empty vaccine containers and vaccination equipment according to local waste disposal regulations after vaccination.
• KEEP OUT OF REACH OF CHILDREN, UNINFORMED PERSONS AND ANIMALS.
• Although this vaccine has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.

PRECAUTIONS

• Vaccinate healthy chickens only.
• Observe aseptic precautions. Ensure that all vaccination equipment (needles, syringes, etc.) are clean and sterile prior to and during use.
• It is essential to adhere to the vaccination program to maintain a satisfactory immune response.
• It is good vaccination practice when handling the vaccine to avoid contact with the eyes, hands and clothing.

DIRECTIONS FOR USE – USE ONLY AS DIRECTED
Shake well before use and at regular intervals during the vaccination process.

RECOMMENDED VACCINATION PROGRAMME
Nobilis^® IB+ND should be given to chickens around 16 to 20 weeks of age, but not less than 4 weeks before the expected onset of lay.
For an optimal booster effect, the chickens must be primed with live vaccines of the separate component strains.
The best results will be obtained if vaccination with inactivated IB vaccine takes place 6 weeks or more after administering the live vaccine but under no circumstances should it be done earlier than 4 weeks after priming.

DOSAGE AND ADMINISTRATION

• Each chicken should be given 0,5 mℓ of the vaccine intramuscularly in the breast muscle or subcutaneously in the back of the neck. (Administration via intramuscular injection into the breast muscle, the needle should be pointed in the direction of the chicken’s head, to prevent the needle from entering the body cavity.)
• Allow the vaccine to gradually reach room temperature (20 °C to 25 °C) prior to use.
• Shake well before use and at regular intervals during the vaccination process.
• Remove the aluminium over seal and the vaccine is ready for use.
• Inject all the chickens in the flock.

IMMUNITY
If priming and subsequent vaccination have been carried out correctly the chickens will develop antibodies at a level which provides protection against Newcastle disease and production losses caused by serotype Massachusetts of Infectious Bronchitis.

VACCINATION REACTIONS
In healthy chickens, no clinical reaction to the vaccination will be observed. For some weeks after vaccination a slight swelling may be felt at the site of the vaccination. This does not constitute permanent tissue damage provided the vaccination has been carried out aseptically.

PRESENTATION
Bottles containing 500 mℓ sufficient for 1 000 doses packed in a outer cardboard box