FOR ANIMAL USE ONLY

INDICATIONS
Nobilis^® IB+ND+EDS is a combined inactivated vaccine for the protection of layers and breeders against Egg Drop Syndrome ’76 and for the booster vaccination of breeding chickens against Newcastle Disease and Massachusetts types of Infectious Bronchitis.

COMPOSITION
Nobilis^® IB+ND+EDS contains immunogenic strains of Infectious Bronchitis virus (Massachusetts), and Newcastle Disease virus and the BC strain 14 Egg Drop Syndrome ’76 virus.
Each 0,5 mℓ dose of Nobilis^® IB+ND+EDS contains immunogenic strains of Infectious Bronchitis virus (Massachusetts) (inducing ≥ 6,0 log₂ HI units), Newcastle disease virus, (containing ≥ to 50 PD₅₀ units), and BC strain 14 of Egg Drop Syndrome ’76 virus (inducing ≥ 6,5 log₂ HI units). The viruses have been inactivated with formalin and subsequently suspended in the water phase of a water-in-oil emulsion.

STORAGE

• Store in the dark between 2 ºC and 8 ºC.
• Do not freeze.
• Avoid prolonged or repetitive exposure to high ambient temperatures following withdrawal from the refrigerator prior to use.
• Protect from direct sunlight.

WARNINGS

• Withdrawal period: Do not market chickens for slaughter purposes for at least 6 weeks after vaccination.
• Avoid intravenousinjection.
• Ensure that chickens marketed do not have swellings at the site of vaccine administration, as this may result in the condemnation of the chickens.
• Do not mix Nobilis^® IB+ND+EDS with other vaccines.
• Vaccination of chickens in production may lead to a slight drop in egg production.
• Accidental self-vaccination may lead to severe local allergic reaction. Consult a physician informing him/her that the vaccine contains a mineral oil.
• Do not store partially used containers for future use and use the entire contents once opened.
• Opened bottles, not used within 24 hours, should be destroyed as well as empty vaccine containers and vaccination equipment according to local waste disposal regulations after vaccination.
• KEEP OUT OF REACH OF CHILDREN, UNINFORMED PERSONS AND ANIMALS.
• Although this vaccine has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.

PRECAUTIONS

• Vaccinate healthy chickens only.
• Observe aseptic precautions. Ensure that all vaccination equipment (needles, syringes, etc.) are clean and sterile prior to and during use.
• It is essential to adhere to the vaccination program to maintain a satisfactory immune response.
• It is good vaccination practice when handling the vaccine to avoid contact with the eyes, hands and clothing.

DIRECTION FOR USE – USE ONLY AS DIRECTED
Shake well before use and at regular intervals during the vaccination process.

RECOMMENDED VACCINATION PROGRAMME
Nobilis^®IB+ND+EDS should be given to chickens around 16 to 20 weeks of age, but not less than 4 weeks before the expected onset of lay.
For an optimal booster effect, the chickens must be primed with live vaccines of the separate component strains.
The best results will be obtained if vaccination with inactivated IB vaccine takes place 6 weeks or more after administering the live vaccine but under no circumstances should it be done earlier than 4 weeks after priming.

DOSAGE AND ADMINISTRATION

• Each chicken should be given 0,5 mℓ of the vaccine intramuscularly into the breast muscle or subcutaneously into the back of the neck. (Intramuscular into the breast muscle, the needle should be pointed in the direction of the chicken’s head to prevent the needle from entering the body cavity.)
• Allow the vaccine to gradually reach room temperature (20 ºC to 25 ºC) prior to use.
• Shake well before use and at regular intervals during the vaccination process.
• Remove the aluminium over seal and the vaccine is ready for use.
• Inject all the chickens in the flock.

IMMUNITY
If priming and subsequent vaccination have been carried out correctly the chickens will develop antibodies at a level which provides protection against Egg Drop Syndrome ’76, Newcastle disease and production losses caused by the Massachusetts serotype of Infectious Bronchitis.

VACCINATION REACTIONS
In healthy chickens, no clinical reaction to the vaccination will be observed. For some weeks after vaccination a slight swelling may be felt at the site of the vaccination. This does not constitute permanent tissue damage provided the vaccination has been carried out aseptically.

PRESENTATION
Bottles containing 500 mℓ sufficient for 1 000 doses packed in an outer cardboard carton.